You can check or change your macro security settings by selecting Tool > Macro > Security from PowerPoint's main pull-down menus.

pptXTREME add-ins are COM add-ins that are installed. If you have checked Trust all installed add-ins and templates, then pptXTREME will run as long as your Security Level is set to High or below. If Trust all installed add-ins and templates is UNchecked then you will be prompted with the Digital Certificated if your Security Level is set to Medium or above.
NOTE: pptXTREME add-ins will not work with your security level set to Very High unless you check the box next to Trust all installed add-ins and templates on the Tursted publishers tab.
For more information about the security warning prompt see Macro Security in the Installation tab of this help file.
For more information about macro security in office applications see this Microsoft® FAQ.